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RH5.2-VLP + Matrix-M
- Development stage
- Unknown
- Lead developer
- University of Oxford
- Modality
- Nanoparticles → Drug Delivery Systems, Recombinant Proteins and Enzymes, Vaccines & Immunotherapeutics
- Administration
- Intramuscular
01
Overview
RH5.2-VLP + Matrix-M is an experimental blood-stage malaria vaccine candidate developed by the University of Oxford. It consists of a re-engineered and stabilized RH5 immunogen (RH5.2) that includes only the alpha-helical core of the Plasmodium falciparum reticulocyte-binding protein homolog 5 (RH5), with disordered regions removed to enhance the induction of growth-inhibitory antibodies. This immunogen is bioconjugated to hepatitis B surface antigen (HBsAg) virus-like particles (VLPs) using SpyTag-SpyCatcher technology and is formulated with Novavax's saponin-based Matrix-M adjuvant. The vaccine aims to prevent malaria by blocking the invasion of human erythrocytes by P. falciparum merozoites.
- Other names
- RH5.2-VLP/Matrix-MRH5.2 + Matrix-M
02
Targets
BSG (Basigin)PfRH5
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