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rho(d) immune globulin
- Development stage
- Approved
- Lead developer
- Grifols
- Modality
- Antibody-Based Therapeutics
- Administration
- Intramuscular, Intravenous
01
Overview
Rho(D) immune globulin is a sterile solution of human polyclonal IgG antibodies directed against the Rh(D) antigen on red blood cells. It is primarily used to prevent Rh isoimmunization in Rh-negative individuals exposed to Rh-positive blood—most commonly in pregnant or postpartum women to prevent hemolytic disease of the fetus and newborn (HDFN). The drug works by binding to any fetal Rh-positive erythrocytes that enter maternal circulation and promoting their clearance before the mother's immune system can mount an antibody response. Rho(D) immune globulin is also indicated for treating immune thrombocytopenic purpura (ITP), where it increases platelet counts by inhibiting autoantibody-mediated platelet clearance. The product is derived from pooled human plasma from immunized donors and administered intramuscularly or intravenously[1][2][4][5].
- Brand names
- HyperRHO S/D Full DoseHyperRHO S/D Mini DoseMicRhoGAM Ultra-Filtered PlusRhoGAM Ultra-Filtered PlusRhophylacWinRho SDF
- Other names
- rhogamrhophylacwinrho sdfhyperrho s/d full dosehyperrho s/d mini dosemicrhogam ultra-filtered plus
02
Targets
FcγR (Low affinity immunoglobulin gamma Fc region receptor II-c)
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