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rilpivirine + raltegravir
- Development stage
- Preclinical
- Lead developer
- Janssen Pharmaceutical
- Modality
- Small Molecules
- Administration
- Oral
01
Overview
TMC278 + raltegravir is a combination of two antiretroviral agents for HIV-1 treatment. Rilpivirine (TMC278) is a next-generation non-nucleoside reverse transcriptase inhibitor (NNRTI) with potent anti-HIV-1 activity and a high barrier to resistance. It inhibits HIV-1 reverse transcriptase, preventing viral DNA synthesis[2]. Raltegravir is an integrase strand transfer inhibitor that blocks HIV-1 integrase, preventing the integration of viral DNA into the host genome[1][5]. Used together, these drugs target separate essential steps of HIV replication: reverse transcription and genome integration. The combination is investigated for nucleoside-sparing regimens or multi-class resistant HIV.
- Other names
- rilpivirineTMC278TMC-278TMC 278raltegravir
02
Targets
Human immunodeficiency virus type 1 reverse transcriptaseIntegrase allosteric pocket (HIV)
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