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rilvegostomig + recombinant human hyaluronidase
- Development stage
- Unknown
- Lead developer
- AstraZeneca
- Modality
- Bispecific Antibodies → Multispecific Antibodies → Engineered Antibody Formats → Antibody-Based Therapeutics, Recombinant Proteins and Enzymes
- Administration
- Subcutaneous
01
Overview
rilvegostomig + recombinant human hyaluronidase is a subcutaneous combination therapy being developed by AstraZeneca for the treatment of advanced solid tumors. The formulation consists of rilvegostomig (AZD2936), a bispecific monoclonal antibody that targets both programmed cell death protein 1 (PD-1) and T-cell immunoreceptor with Ig and ITIM domains (TIGIT), and recombinant human hyaluronidase (rHu). Rilvegostomig is designed to enhance antitumor immune activity by simultaneously blocking two key inhibitory checkpoints on T cells. The recombinant human hyaluronidase component acts as a permeation enhancer by temporarily degrading hyaluronan in the subcutaneous extracellular matrix, which facilitates the delivery and absorption of large volumes of the bispecific antibody. This combination is currently being evaluated in the Phase I ARTEMIDE-subQ trial to compare its pharmacokinetics and safety with intravenous administration of rilvegostomig.
- Other names
- SC rilvegostomigrilvegostomig subcutaneousrecombinant human hyaluronidase-AstraZeneca-advanced solid tumorsrHurHuPH20rHuPH-20rHuPH 20
02
Targets
PDCD1 (Programmed cell death protein 1 receptor)TIGIT (T cell immunoreceptor with Ig and ITIM domains)
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