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Ringer's acetate solution is a balanced isotonic crystalloid used for intravenous fluid replacement and volume expansion. It contains sodium chloride, potassium chloride, calcium chloride, and sodium acetate. The inclusion of acetate serves as a buffering agent; acetate is rapidly metabolized in various tissues (including muscle) to bicarbonate, helping to maintain or correct acid-base balance without the hepatic load associated with lactate-buffered solutions. In clinical research conducted by Mansoura University, it is utilized as a coloading fluid to stabilize maternal hemodynamics and cardiac output in preeclamptic patients undergoing Cesarean section under spinal anesthesia, a population at high risk for hypotension and fluid-related complications.
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