risedronate + cholecalciferol

Risedronate + cholecalciferol is a fixed-dose combination of two agents used primarily for the prevention and treatment of osteoporosis and related bone disorders. Risedronate is a third-generation bisphosphonate that inhibits bone resorption by binding to hydroxyapatite in bone and inducing osteoclast apoptosis through inhibition of farnesyl pyrophosphate synthase, thereby reducing bone breakdown and increasing bone density[1][5][6]. Cholecalciferol (vitamin D3) is a dietary supplement that increases intestinal absorption of calcium, supporting healthy bone mineralization[3]. The combination addresses both decreased bone formation (via vitamin D deficiency) and increased resorption (via osteoclast activity), making it effective for conditions such as postmenopausal osteoporosis, glucocorticoid-induced osteoporosis, male osteoporosis, and Paget’s disease[1][2][4].

Other names

risedronic acidvitamin D3