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Drug intelligence / Profile preview
risperidone + haloperidol
- Development stage
- Phase 4
- Lead developer
- Johnson & Johnson
- Modality
- Small Molecules
- Administration
- Oral
01
Overview
Risperidone and haloperidol are both antipsychotic medications. Risperidone is a benzisoxazole derivative, while haloperidol is a butyrophenone. Both are primarily dopamine receptor antagonists, with risperidone also acting as a serotonin 5-HT2A receptor antagonist. They are widely used in the treatment of psychiatric conditions such as schizophrenia and manic episodes associated with bipolar disorder. Clinical trials have also investigated their use in delirium, though some studies suggest they may not be more effective than placebo for this indication and can be associated with significant side effects like hyperprolactinemia and extrapyramidal symptoms.
- Other names
- risperidone, haloperidol
02
Targets
ADRA1A (α1A)ADRA2A (α2A)DRD1 (Dopamine D1 Receptor)DRD2 (Dopamine D2 Receptor)DRD3 (Dopamine receptor D3)DRD4 (Dopamine D4 Receptor)HRH1 (Histamine H1 Receptor)M1 (Muscarinic acetylcholine receptor M1)HTR1A (Serotonin receptor 1A (5-hydroxytryptamine receptor 1A))HTR2A (Serotonin receptor 5-HT2A)HTR2C (5-hydroxytryptamine 2C receptor)
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