rNAPc2 + 5-fluorouracil

rNAPc2 + 5-fluorouracil is an investigational combination drug regimen being studied for the treatment of metastatic colorectal cancer. rNAPc2 is a recombinant protein derived from a nematode anticoagulant found in hookworm saliva, functioning as an inhibitor of the factor VIIa/tissue factor protease complex, thereby blocking coagulation and impacting processes such as metastasis and angiogenesis in cancer. 5-fluorouracil (5-FU) is an antimetabolite chemotherapeutic agent that disrupts DNA and RNA synthesis in cancer cells, primarily by inhibiting thymidylate synthase and incorporating into RNA, ultimately inducing cell death. The combination aims to suppress tumor growth through synergistic effects on cancer progression and angiogenesis, while providing anticoagulation[1][4][5][6][7].

Brand names

Adrucil

Other names

rNAPc2rNAPc-2rNAPc 2recombinant nematode anticoagulant protein c25-fluorouracil5-FU