RO5479599 + zirconium-89-labeled RO5479599

RO5479599 + zirconium-89-labeled RO5479599 is a combination of RO5479599, an experimental anti-HER3 monoclonal antibody, and a radiolabeled form of RO5479599 tagged with zirconium-89 for imaging and diagnostic purposes. RO5479599 binds the HER3 receptor, leading to inhibition of HER3 signaling and induction of tumor cell apoptosis in HER3-overexpressing tumors, especially non-small cell lung cancer (NSCLC) of squamous histology. The zirconium-89-labeled variant provides molecular imaging capability via PET/CT scans, allowing for biodistribution, target engagement, and pharmacokinetic assessments. This combination allows both therapeutic targeting and real-time tracking of antibody localization and efficacy in solid tumors[1][2].

Other names

RO5479599RO-5479599RO 5479599lumretuzumabzirconium-89-labeled RO5479599zirconium89-labeled RO5479599zirconium 89-labeled RO5479599