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RO5503781 + posaconazole
- Development stage
- Unknown
- Lead developer
- Roche
- Modality
- Small Molecules
- Administration
- Oral
01
Overview
**RO5503781 + posaconazole** is an investigational combination of RO5503781, a small molecule cancer growth inhibitor, and posaconazole, a triazole antifungal agent. RO5503781 acts as a biological therapy and cancer growth blocker, disrupting signals necessary for cancer cells to divide and proliferate. Posaconazole inhibits 14-alpha demethylase in fungi, blocking ergosterol synthesis, and is used to treat and prevent invasive fungal infections, especially in immunocompromised patients. The combination has been studied in clinical trials, primarily to assess pharmacokinetics, safety, and drug-drug interaction in patients with solid tumors, with particular interest in mutual pharmacological influences and safety profile[2][3][7].
- Other names
- RO5503781RO-5503781RO 5503781posaconazole
02
Targets
CYP3A4 (Cytochrome P450 3A4)MDM2 (Mouse double minute 2 homolog)CYP51A1 (Sterol 14α-demethylase)
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