ro7049389 + nucleoside analogue

RO7049389 + nucleoside analogue is a combination therapy under investigation for chronic hepatitis B infection. **RO7049389** is a small molecule **core protein allosteric modulator** that disrupts the hepatitis B virus (HBV) core protein, impairing the viral replication cycle. Nucleoside analogues (NUCs), such as entecavir or tenofovir, inhibit the HBV DNA polymerase, providing potent suppression of viral replication. In clinical studies, RO7049389 in combination with nucleoside analogues is being evaluated for additive or synergistic antiviral effects, aiming to achieve deeper viral suppression or functional cure in chronic hepatitis B[1][2][3]. The combination may also be studied with pegylated interferon, but the canonical definition is RO7049389 plus a nucleoside analogue.