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RO7445482 + nucleos(t)ide
- Development stage
- Unknown
- Lead developer
- Roche
- Modality
- Small Molecules, Chemically Modified siRNA → Small Interfering RNA (siRNA) → Small RNA Therapeutics → RNA Therapeutics → Nucleic Acid Therapeutics, Conjugated siRNA → Small Interfering RNA (siRNA) → Small RNA Therapeutics → RNA Therapeutics → Nucleic Acid Therapeutics
- Administration
- Subcutaneous, Oral
01
Overview
RO7445482, also known as xalnesiran or RG6346, is a liver-targeted, GalNAc-conjugated short-interfering RNA (siRNA) designed to inhibit hepatitis B virus (HBV) gene expression by targeting the S open reading frame of the HBV genome. When combined with a nucleos(t)ide analogue (e.g., entecavir, tenofovir disoproxil fumarate, or tenofovir alafenamide), it is under investigation as a combination therapy for chronic hepatitis B infection. The nucleos(t)ide component acts as a direct-acting antiviral that inhibits HBV reverse transcriptase, thus suppressing viral replication, while RO7445482 reduces HBV gene expression to lower viral antigen production. This combination aims to achieve a functional cure in chronic HBV-infected patients.
- Other names
- xalnesiran + nucleos(t)ide analogue
02
Targets
HBV (Hepatitis B virus)HBV Pol (Hepatitis B virus polymerase)
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