rocuronium + remifentanil

Rocuronium + remifentanil is a combination of two intravenous drugs commonly used in anesthesia. Rocuronium is a non-depolarizing neuromuscular blocking agent (muscle relaxant) that acts as a competitive antagonist at nicotinic acetylcholine receptors at the neuromuscular junction, leading to skeletal muscle relaxation and facilitating tracheal intubation or surgery. Remifentanil is an ultra-short-acting synthetic opioid analgesic that acts as an agonist at µ-opioid receptors, providing potent pain relief and blunting hemodynamic responses during surgical procedures. Remifentanil has rapid onset and offset due to its unique metabolism by nonspecific esterases in blood and tissues, independent of liver function[1][3][4][6]. The combination is used for induction and maintenance of general anesthesia, with remifentanil often administered before rocuronium to reduce withdrawal movements caused by rocuronium injection[2].

Other names

rocuronium bromideremifentanil hydrochloride