Drug intelligence / Profile preview

rose geranium + sesame oil

Development stage
Unknown
Lead developer
Mayo Clinic
Modality
Metabolically Activated Prodrugs → Prodrugs/Conditional Activator Small Molecules → Small Molecules, Classical Binding Small Molecules → Small Molecules
Administration
Topical, Intranasal
01

Overview

Rose geranium in sesame oil is a topical botanical formulation administered as a nasal spray, primarily investigated for the treatment of nasal vestibulitis and epistaxis. Nasal vestibulitis is a common side effect of cancer therapies, particularly taxane-based chemotherapy, characterized by nasal dryness, bleeding, and sores. The formulation consists of rose geranium oil (derived from the *Pelargonium graveolens* plant) in a sesame oil base. Clinical studies, including a Phase III trial conducted by the Mayo Clinic, have demonstrated its efficacy in improving nasal symptoms and reducing the severity of nosebleeds in patients with hereditary hemorrhagic telangiectasia (HHT). The product acts as an emollient and protective barrier for the nasal mucosa.

Other names
rose geranium in sesame oilrose geranium oil in sesame oilrose geranium nasal spray

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