Drug intelligence / Profile preview

rosemary + quercetin + turmeric

Development stage
Unknown
Modality
Small Molecules
Administration
Oral
01

Overview

A combination product containing **rosemary (Rosmarinus officinalis)**, **quercetin** (a naturally occurring polyphenol), and **turmeric (Curcuma longa)** has been used primarily as a dietary supplement to support a healthy inflammatory response and antioxidant status. The combination leverages antioxidant and anti-inflammatory properties of each component: - **Turmeric**: Contains curcuminoids (such as curcumin) that inhibit the expression of pro-inflammatory cytokines (TNF-α, IL-1), NF-κB, and contribute to antioxidative defense by neutralizing reactive oxygen species (ROS)[1][3]. - **Quercetin**: A flavonoid that reduces oxidative stress and inhibits inflammatory signaling (e.g., NF-κB), and may help modulate immune function[1]. - **Rosemary**: Contains carnosic acid; shown to downregulate pro-inflammatory cytokine expression, inhibit osteoclastogenesis, and suppress pathways such as 5-lipoxygenase and PGE2[1][3]. This combination may be used for promoting joint health, supporting tissue repair after injury, maintaining antioxidant status, and reducing markers of oxidative stress. Its mechanism includes inhibition of COX-2 enzymes (pro-inflammatory) and modulation of oxidative/inflammatory pathways. It is not a pharmaceutical drug but marketed as a dietary supplement for general wellness[1][3].

02

Targets

PTGS2 (Prostaglandin-Endoperoxide Synthase 2)ALOX12 (Arachidonate 12-lipoxygenase, 12S type)TNFA (Tumor necrosis factor alpha (soluble))NF-κBIL1A (Interleukin 1 alpha)

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