rosuvastatin + BAY1817080

Rosuvastatin + BAY1817080 is a combination of two drugs studied for potential drug-drug interactions. Rosuvastatin is an HMG-CoA reductase inhibitor (statin) used to lower cholesterol and reduce the risk of cardiovascular events such as heart attack and stroke. It works by inhibiting the enzyme 3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMG-CoA reductase) in the liver, reducing cholesterol synthesis, increasing hepatic LDL receptor expression, and enhancing clearance of LDL from the bloodstream[1][3][5][6]. BAY1817080 is an investigational small molecule developed by Bayer with a mechanism aimed at suppressing pain and chronic cough; it acts by binding to and blocking proteins related to pain signaling[2]. The combination has been studied in healthy adults to assess how BAY1817080 affects the pharmacokinetics of rosuvastatin due to potential shared protein targets involved in drug absorption or metabolism[2].

Brand names

CrestorEzallor SprinkleRoszet

Other names

rosuvastatin calcium