Drug intelligence / Profile preview

rosuvastatin + omega-3

Development stage
Preclinical
Lead developer
Hanmi Pharmaceutical
Modality
Small Molecules
Administration
Oral
01

Overview

**Rosuvastatin + omega-3** is a combination therapy consisting of the HMG-CoA reductase inhibitor rosuvastatin and omega-3 fatty acids, primarily used in patients with dyslipidemia, residual hypertriglyceridemia, and/or cardiometabolic risk. Rosuvastatin lowers cholesterol levels by inhibiting HMG-CoA reductase, and omega-3 fatty acids (mainly EPA and DHA) reduce triglycerides and have anti-inflammatory and vascular protective effects. This combination is not an FDA-approved fixed-dose product but represents a regimen frequently studied for synergistic lipid-lowering and cardiovascular risk reduction. Combination therapy shows greater improvements in triglycerides, non-HDL cholesterol, endothelial function, and adiponectin levels compared to either agent alone, without increasing adverse events[1][2][3][4][5].

Other names
rosuvastatin and omega-3 fatty acidsrosuvastatin plus omega-3rosuvastatin/omega-3
02

Targets

HMGCR (3-hydroxy-3-methylglutaryl-coenzyme A reductase)PPARG (Peroxisome proliferator-activated receptor gamma)

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