Drug intelligence / Profile preview

rosuvastatin + ramipril

Development stage
Unknown
Lead developer
Cardiology Research, University of British Columbia
Modality
Small Molecules
Administration
Oral
01

Overview

A combination regimen consisting of the HMG-CoA reductase inhibitor rosuvastatin and the angiotensin-converting enzyme (ACE) inhibitor ramipril, currently being investigated in the Phase 4 SAFER-SCAD (Statin and ACE Inhibitor in SCAD) clinical trial. This study, led by Cardiology Research UBC, focuses on women who have previously experienced spontaneous coronary artery dissection (SCAD) and continue to suffer from persistent angina and microvascular coronary dysfunction. Rosuvastatin is a small molecule statin that lowers LDL cholesterol and provides pleiotropic vascular benefits, such as improved endothelial function. Ramipril is a small molecule ACE inhibitor that reduces vasoconstriction and improves microcirculatory resistance. The combination is intended to address the underlying microvascular issues that often persist after the initial arterial dissection has healed.

Other names
SAFER-SCAD interventionrosuvastatin and ramipril
02

Targets

HMGCR (3-hydroxy-3-methylglutaryl-coenzyme A reductase)ACE (Angiotensin Converting Enzyme)

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