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A combination regimen consisting of the HMG-CoA reductase inhibitor rosuvastatin and the angiotensin-converting enzyme (ACE) inhibitor ramipril, currently being investigated in the Phase 4 SAFER-SCAD (Statin and ACE Inhibitor in SCAD) clinical trial. This study, led by Cardiology Research UBC, focuses on women who have previously experienced spontaneous coronary artery dissection (SCAD) and continue to suffer from persistent angina and microvascular coronary dysfunction. Rosuvastatin is a small molecule statin that lowers LDL cholesterol and provides pleiotropic vascular benefits, such as improved endothelial function. Ramipril is a small molecule ACE inhibitor that reduces vasoconstriction and improves microcirculatory resistance. The combination is intended to address the underlying microvascular issues that often persist after the initial arterial dissection has healed.
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