Drug intelligence / Profile preview

RSVPreF3 + quadrivalent influenza vaccine

Development stage
Unknown
Lead developer
GSK
Modality
Recombinant Proteins and Enzymes, Vaccines & Immunotherapeutics
Administration
Intramuscular
01

Overview

A combination vaccine product consisting of the RSVPreF3 vaccine (based on the recombinant prefusion F protein of respiratory syncytial virus, stabilized in its pre-fusion conformation) together with a quadrivalent influenza vaccine. RSVPreF3 is primarily composed of the recombinant RSV prefusion F protein, used with the AS01E adjuvant (containing QS-21 and monophosphoryl lipid A), and is designed to elicit protective immunity against RSV. The quadrivalent influenza vaccine contains inactivated antigens from four distinct influenza strains, providing broad influenza coverage. Coadministration of these vaccines is shown to be immunogenic, safe, and generally well tolerated in older adults[3][5]. The primary indication is prevention of lower respiratory tract disease caused by RSV and seasonal influenza, especially in adults aged 60 years and older[3][5].

Brand names
Abrysvo
Other names
RSVPreF3 OARSVPreF-3 OARSVPreF 3 OARSV prefusion F protein-based vaccine coadministered with quadrivalent influenza vaccine
02

Targets

RSV F (Respiratory syncytial virus fusion protein)HA (Influenza virus hemagglutinin antigens from four strains)

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