RV4104A + ciclopiroxolamine + ciclopirox

This is a **combination antifungal therapy** consisting of three topical agents: RV4104A ointment, ciclopiroxolamine cream, and ciclopirox film-forming solution. This sequential regimen has been studied primarily for the treatment of **dermatophytic onychomycosis (toenail fungal infection) without matrix involvement**. All components are broad-spectrum antifungals applied topically, working primarily by disrupting essential cofactors and membrane function within the fungal cell. Ciclopirox and ciclopiroxolamine (the ethanolamine salt of ciclopirox) act via **chelation of polyvalent metal cations (mainly Fe3+ and Al3+)**, inhibiting fungal enzyme systems needed for cell metabolism and the integrity of fungal cell structure, leading to inhibition of cell growth and division. RV4104A is an ointment evaluated in clinical trials for use as part of this sequential approach[3][7].

Other names

RV4104A ointment + ciclopiroxolamine cream + ciclopirox film-forming solution