rVSV(M51)-M3

rVSV(M51)-M3 is a genetically engineered, replication-competent recombinant vesicular stomatitis virus (VSV) with a deletion/mutation at position 51 (MΔ51) in the matrix (M) protein and engineered to express M3—a secreted chemokine-binding protein derived from murine gammaherpesvirus-68. Its primary mechanism is oncolytic: it infects and lyses tumor cells while the M3 protein suppresses host inflammatory chemokine responses within the tumor microenvironment. This action results in enhanced viral replication within tumors, increased tumor necrosis, and reduced recruitment of immune cells (such as neutrophils and natural killer cells) that would otherwise limit viral spread. Preclinical studies show it is safe and effective in animal models of multifocal hepatocellular carcinoma (HCC), achieving long-term tumor-free survival in a significant number of treated animals, with no observed systemic or organ toxicity[2][4].

Other names

rVSV(MΔ51)-M3rVSV(M Delta 51)-M3