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RZL-012 + lidocaine
- Development stage
- Phase 2
- Lead developer
- Raziel Therapeutics
- Modality
- Orthosteric Ligands → Classical Binding Small Molecules → Small Molecules
- Administration
- Subcutaneous
01
Overview
RZL-012 is a novel investigational small molecule (5-[3,6-dibromo-9H-carbazol-9-yl]-N,N,N-trimethylpentan-1-aminium chloride) developed for subcutaneous injection to reduce localized fat. Its mechanism of action involves direct disruption of adipocyte cell membrane integrity, leading to adipocyte death (liponecrosis), followed by an inflammatory response and replacement of dead fat tissue with fibrotic tissue. This process results in significant reduction in fat volume at the treated site[1][6][8]. RZL-012 is being studied for conditions such as submental fat, obesity, and Dercum disease (adiposis dolorosa). In some clinical trials, RZL-012 is administered with lidocaine (a local anesthetic) to improve patient comfort during injection[4]. The drug is under development by Raziel Therapeutics and Yissum Research Development Company[3].
- Other names
- tapencarium + lidocaine
02
Targets
SCN5A (Sodium channel protein type 5 subunit alpha)
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