S-(N-hydroxy-N-iodophenylcarbamoyl)glutathione

S-(N-hydroxy-N‑iodophenylcarbamoyl)glutathione is a synthetic small molecule derivative of glutathione, in which the glutathione moiety is conjugated to an N-hydroxy-N‑iodophenyl carbamoyl group. It has been studied primarily as an experimental inhibitor and ligand for glyoxalase I (also known as lactoylglutathione lyase), an enzyme involved in the detoxification of methylglyoxal via the glyoxalase system. Structural studies have shown that this compound binds to human glyoxalase I, making it useful for probing enzyme mechanism and structure-function relationships[4][7]. There are no approved therapeutic indications or clinical trials reported for this compound; its use is limited to biochemical and structural research.

Other names

(2S)-2-amino-5-[[(2R)-1-(carboxymethylamino)-3-[(R)-hydroxy-(N-hydroxy-4-iodoanilino)methyl]sulfanyl-1-oxopropan-2-yl]amino]-5-oxopentanoic acid(2S)-2-amino-4-{[(1R)-1-[(carboxymethyl)carbamoyl]-2-{[(R)-hydroxy[hydroxy(4‑iodophenyl)amino]methyl]sulfanyl}ethyl]carbamoyl}butanoic acidL-gamma-glutamyl-S-{(R)-hydroxy[hydroxy(4​-iodophenyl)amino]methyl}-L-cysteinylglycine