Drug intelligence / Profile preview

S-1 + amrubicin

Development stage: Preclinical
Lead developer: Bristol Myers Squibb
Modality: Small Molecules
Administration: Oral, Intravenous

Overview

S-1 + amrubicin is a combination chemotherapy regimen consisting of S-1 (an oral fluoropyrimidine) and amrubicin (a totally synthetic 9-aminoanthracycline). Amrubicin is an anthracycline anticancer agent that has shown activity against non-small-cell lung cancer (NSCLC) and small-cell lung cancer (SCLC). In clinical trials, amrubicin has been studied in combination with platinum agents like cisplatin, showing promising efficacy and manageable toxicity profiles.

Targets

TOP2A (DNA topoisomerase II)TS (Thymidylate synthase)

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