Drug intelligence / Profile preview

s-adenosyl-l-methionine + vitamin B complex

Development stage
Unknown
Modality
Orthosteric Ligands → Classical Binding Small Molecules → Small Molecules, Metabolically Activated Prodrugs → Prodrugs/Conditional Activator Small Molecules → Small Molecules
Administration
Oral
01

Overview

This is a combination dietary supplement containing s-adenosyl-l-methionine (SAMe) and a vitamin B complex. SAMe is a naturally occurring compound in the body involved in methylation reactions essential for neurotransmitter synthesis, DNA regulation, and liver function. It has been studied primarily for depression, osteoarthritis, and liver diseases. Vitamin B complex typically includes vitamins such as thiamine (B1), riboflavin (B2), niacin (B3), pantothenic acid (B5), pyridoxine (B6), biotin (B7), folate (B9), and cobalamin (B12). These vitamins are crucial co-factors in metabolic pathways including those involving SAMe; specifically, vitamins B6, B9, and B12 are required for optimal methylation processes. The combination is often marketed to support mood health, joint comfort, cognitive function, energy metabolism, and liver health. This product is sold as a dietary supplement rather than an approved pharmaceutical drug.

Other names
SAMe + vitamin B complexS-adenosylmethionine + vitamin B complexademetionine + vitamin B complex
02

Targets

Folate-dependent 1-carbon transfer enzymesDNMT (DNA methyltransferase)MTR (Methionine synthase)

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