s-amlodipine + valsartan + indapamide

s-amlodipine + valsartan + indapamide is a fixed-dose combination drug used for the treatment of **hypertension** (high blood pressure). It combines three active pharmaceutical ingredients: - **S-amlodipine**: a calcium channel blocker (specifically the active S-enantiomer of amlodipine) that inhibits calcium influx into vascular smooth muscle and cardiac muscle, resulting in vasodilation and lowering of blood pressure. - **Valsartan**: an angiotensin II receptor blocker (ARB) that blocks the effects of angiotensin II on its AT1 receptor, resulting in vasodilation, decreased aldosterone secretion, and reduced blood pressure. - **Indapamide**: a thiazide-like diuretic that works primarily at the distal nephron in the kidney, promoting natriuresis (excretion of sodium) and diuresis (excretion of water), thereby reducing blood volume and blood pressure. The triple combination leverages complementary mechanisms to lower blood pressure more effectively and help achieve greater blood pressure control in patients not adequately managed by monotherapy or dual therapy. This medication is indicated for the management of hypertension and may help reduce the risk of cardiovascular events such as stroke and myocardial infarction in patients with high blood pressure[1][2][3].

Brand names

AGSAVI

Other names

indapamide/valsartan/levamlodipine maleate