Drug intelligence / Profile preview

S-methyl-4,5,6,7-tetrabromo-benzimidazole

Development stage
Unknown
Lead developer
Daiichi Sankyo
Modality
Small Molecules
01

Overview

S-methyl-4,5,6,7-tetrabromo-benzimidazole is a synthetic small molecule with the chemical formula C8H4Br4N2S and a molecular weight of approximately 479.81 g/mol[1][2][3]. It is structurally characterized as a benzimidazole derivative substituted with four bromine atoms and an S-methyl group. This compound has been listed in pharmaceutical databases such as ZINC15 and DrugBank as an experimental agent[1][2]. While detailed pharmacological data are limited for this specific methylated derivative (as opposed to the closely related non-methylated analogs), it belongs to the class of benzimidazoles known for their kinase inhibitory activity. The parent scaffold (tetrabromobenzimidazole) is recognized as a potent and selective inhibitor of casein kinase II (CK2), acting in an ATP/GTP competitive manner; however direct evidence for CK2 inhibition by this methylated analog is not explicitly documented in major drug databases[5][6]. No approved therapeutic indications or clinical trial data are available for this compound.

Other names
S-methyl-4,5,6,7-tetrabromo-benzimidazole4,5,6,7-tetrabromo-2-(methylsulfanyl)-1H-1,3-benzodiazole4,5,6,7-TETRABROMO-2-(METHYLSULFANYL)-1H-BENZIMIDAZOLE
02

Targets

CK2 (Casein kinase II subunit alpha)

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