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Saccharomyces boulardii (Biocodex)
- Development stage
- Unknown
- Modality
- Synthetic Biology Platforms → Engineered Microbial Therapeutics → Microbiome Therapeutics, Fresh FMT → Fecal Microbiota Transplantation (FMT) → Microbiome Therapeutics, Yeast Strains → Single Strain Products → Live Biotherapeutic Products → Microbiome Therapeutics, Bacterial Strains → Single Strain Products → Live Biotherapeutic Products → Microbiome Therapeutics, Defined Consortia → Multi-strain Products → Live Biotherapeutic Products → Microbiome Therapeutics, Frozen FMT → Fecal Microbiota Transplantation (FMT) → Microbiome Therapeutics, Genetically Modified Bacteria → Engineered Microbial Therapeutics → Microbiome Therapeutics, Microbial Metabolites → Microbiome-Derived Products → Microbiome Therapeutics, Microbial Proteins → Microbiome-Derived Products → Microbiome Therapeutics, Complex Communities → Multi-strain Products → Live Biotherapeutic Products → Microbiome Therapeutics
- Administration
- Oral
01
Overview
**Saccharomyces boulardii** is a nonpathogenic probiotic yeast used orally to support management of diarrheal illnesses. In the registered study sponsored by Muhammad Aamir Latif, it was administered with zinc to children younger than 5 years with acute watery diarrhea and was compared with zinc alone. The study was completed and evaluated time to resolution of diarrhea and vomiting. Proposed effects include modulation of intestinal microbial ecology, reduction of pathogen and toxin activity, support of epithelial barrier function, and modulation of local intestinal immune responses.
- Brand names
- Ultra-LevuraFlorastorEnterolBioflorReflorPerenterol
- Other names
- S. boulardii
02
Targets
TcdA (Clostridioides difficile toxin A)CTX (Cholera toxin)Sucrase-IsomaltaseCFTR NBD1 (Cystic fibrosis transmembrane conductance regulator nucleotide-binding domain 1)
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