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saffron extract + gynostemma extract + hesperidin
- Development stage
- Unknown
- Lead developer
- LifeExtension
- Modality
- Small Molecules
- Administration
- Oral
01
Overview
This is a **combination dietary supplement** containing saffron extract, gynostemma pentaphyllum extract, and hesperidin. Saffron extract is known for its antioxidant and anti-inflammatory effects. Gynostemma extract (commonly standardized as ActivAMP®, a branded form) is used for metabolic health and exerts its effects primarily by **activating AMP-activated protein kinase (AMPK)**, which supports cellular energy homeostasis and fat metabolism[3][5][7]. Hesperidin is a citrus bioflavonoid with antioxidant, anti-inflammatory, and vasoprotective properties[2][4][6]. The combination is primarily investigated and marketed for use in **weight management**, improving body composition, supporting cardiovascular health, and promoting healthy metabolism[1][3][5][7].
- Brand names
- AMPK Metabolic Activator
- Other names
- saffron extract + gynostemma extract + hesperidingynostemma pentaphyllum extract + hesperidin + saffron extractActivAMP + hesperidin + saffron extract
02
Targets
NOS3 (eNOS)AMPK (Adenosine monophosphate–activated protein kinase)TLR4 (Toll-like receptor 4)
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