Saint Joseph's Univ. GLP-1R compound 7

Saint Joseph's Univ. GLP-1R compound 7: sourced facts only. name: "Co-treatment of 7 with sitagliptin, an inhibitor of GLP-1 degrading enzyme Dipeptidyl Peptidase IV, further confirmed 7 to be an effective PAM of GLP-1R." [PMID:39116711]; target: "Co-treatment of 7 with sitagliptin, an inhibitor of GLP-1 degrading enzyme Dipeptidyl Peptidase IV, further confirmed 7 to be an effective PAM of GLP-1R." [PMID:39116711]; developer: "Department of Chemistry and Biochemistry, Saint Joseph's University, Philadelphia, PA 19104, USA." [PMID:39116711]; modality: "As a step toward the development of novel small-molecule positive allosteric modulators (PAMs) of glucagon-like peptide 1 receptor (GLP-1R) for the treatment of type 2 diabetes, obesity, and heart diseases, we discovered a novel 2-amino-thiophene (2-AT) based lead compound bearing an ethyl 3-carboxylate appendage." [PMID:39116711]