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salbutamol + ipratropium bromide + methacholine
- Development stage
- Unknown
- Lead developer
- Assistance publique - Hôpitaux de Paris
- Modality
- Small Molecules
- Administration
- Inhalation
01
Overview
This research intervention is a combination of bronchodilators and a bronchoconstrictor used in the VACUVOL physiological study (NCT01491308) conducted by Assistance Publique - Hôpitaux de Paris. The protocol involves the administration of salbutamol (a beta-2 adrenergic agonist) and ipratropium bromide (a muscarinic antagonist) to induce bronchodilation, followed by a methacholine (a cholinergic agonist) challenge. The study investigates the paradoxical reduction in maximum expiratory flow (MEF) in healthy subjects under chest wall strapping, exploring the "stiffening" role of bronchial smooth muscle at low lung volumes. It is primarily a physiological research tool rather than a therapeutic drug development program for asthma.
- Other names
- bronchodilators + methacholine-Assistance Publique - Hôpitaux de Paris-asthmaInhaled Bronchodilators +/- Inhaled MethacholineSalbutamol + Ipratropium bromide + Methacholine
02
Targets
ADRB2 (β2)CHRM2 (M2)CHRM3 (M3)
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