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Salbutamol + prednisolone is a combination therapy consisting of two active pharmaceutical ingredients commonly used in the management of acute asthma and other respiratory conditions. Salbutamol (also known as albuterol) is a selective beta-2 adrenergic receptor agonist that acts as a bronchodilator, relaxing airway smooth muscle to relieve bronchospasm and improve airflow. Prednisolone is a synthetic glucocorticoid corticosteroid that exerts anti-inflammatory effects by binding to the glucocorticoid receptor, inhibiting pro-inflammatory signals, and promoting anti-inflammatory pathways. The combination is often used in acute exacerbations of asthma or wheezing disorders—salbutamol provides rapid symptomatic relief by opening airways, while prednisolone addresses underlying airway inflammation[1][2][7]. This dual approach can accelerate recovery in some patients with acute respiratory distress but may offer only transient additional benefit over salbutamol alone for certain indications[7].
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