Drug intelligence / Profile preview

salbutamol + salmeterol + fluticasone

Development stage
Preclinical
Lead developer
GSK
Modality
Orthosteric Ligands → Classical Binding Small Molecules → Small Molecules
Administration
Inhalation
01

Overview

This is a triple combination drug consisting of salbutamol, salmeterol, and fluticasone. Salbutamol (also known as albuterol) is a short-acting beta2-adrenergic agonist (SABA) that provides rapid relief of bronchospasm by relaxing airway smooth muscle. Salmeterol is a long-acting beta2-adrenergic agonist (LABA) that provides prolonged bronchodilation for maintenance therapy in asthma and chronic obstructive pulmonary disease (COPD). Fluticasone is an inhaled corticosteroid that reduces airway inflammation and prevents exacerbations in asthma and COPD. This combination would theoretically provide both immediate symptom relief (via salbutamol), long-term bronchodilation (via salmeterol), and anti-inflammatory effects (via fluticasone). However, there are no widely approved or marketed products containing all three agents together; most commonly available combinations include only fluticasone with salmeterol[1][3][4]. The addition of salbutamol to this fixed-dose combination would be unusual for maintenance therapy but could be considered for specific clinical scenarios.

Other names
inhalation-Fraunhofer-Institute of Toxicology and Experimental Medicine-asthma-chronic obstructive pulmonary disease
02

Targets

ADRB3 (β3)ADRB2 (β2)GR (Glucocorticoid receptor)ADRB1 (β1)

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