Drug intelligence / Profile preview

saline + succinylcholine

Development stage
Unknown
Lead developer
Merck
Modality
Small Molecules
Administration
Intravenous, Intramuscular
01

Overview

This is a combination of two agents: - **Saline** (sterile sodium chloride solution) is an inert isotonic fluid commonly used as a vehicle for intravenous drug administration, dilution, or as an intravenous fluid for hydration and electrolyte balance. - **Succinylcholine** (also known as suxamethonium) is a depolarizing neuromuscular blocker used to induce skeletal muscle relaxation during surgical procedures, facilitate tracheal intubation, and provide muscle paralysis during mechanical ventilation. Succinylcholine acts by binding to post-synaptic cholinergic receptors at the motor endplate of skeletal muscles, causing persistent depolarization and subsequent paralysis. It has rapid onset (within 60 seconds) and short duration of action (4–6 minutes). It does not affect consciousness or pain perception[1][3][5][8].

Brand names
AnectineQuelicin
Other names
saline and succinylcholinesaline plus succinylcholine
02

Targets

CHRM2 (M2)Muscle-type nicotinic acetylcholine receptorCHRM3 (M3)

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