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sanggua (Tongji Hospital)
- Development stage
- Unknown
- Lead developer
- Tongji Hospital
- Modality
- Metabolically Activated Prodrugs → Prodrugs/Conditional Activator Small Molecules → Small Molecules, Classical Binding Small Molecules → Small Molecules
- Administration
- Oral
01
Overview
Sanggua is a Traditional Chinese Medicine (TCM) formula developed as a tablet for the treatment of impaired glucose tolerance (IGT) and mild type 2 diabetes mellitus (T2DM). The formula is composed of five primary botanical ingredients: mulberry leaf (*Folium Mori*), bitter melon (*Fructus Momordicae Charantiae*), kudzu root (*Radix Puerariae*), Chinese yam (*Rhizoma Dioscoreae*), and cassia seed (*Semen Cassiae*). Mechanistically, it is designed to clear heat, generate body fluids, and tonify the spleen and kidneys according to TCM principles. Modern pharmacological studies suggest that its active components, such as mulberry polysaccharides and bitter melon saponins, contribute to blood glucose reduction and lipid profile improvement. It is currently being evaluated in clinical trials led by Tongji Hospital to assess its efficacy on glycated hemoglobin (HbA1c) levels and its impact on the gut microbiota.
- Brand names
- Sanggua
- Other names
- Sanggua tablets
02
Targets
Sucrase-Isomaltase
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