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saredutant + paroxetine
- Development stage
- Phase 3
- Lead developer
- Sanofi
- Modality
- Small Molecules
- Administration
- Oral
01
Overview
Saredutant + paroxetine is an experimental **fixed-dose combination** therapy consisting of saredutant, a neurokinin-2 (NK2) receptor antagonist, and paroxetine, a selective serotonin reuptake inhibitor (SSRI). This combination was investigated in **Phase 3 clinical trials** for **major depressive disorder** (MDD), with the hypothesis that adding saredutant to standard SSRI therapy could improve antidepressant efficacy. Saredutant is designed to modulate neuropeptide signaling pathways implicated in depression and anxiety, while paroxetine is an established antidepressant acting through serotonergic mechanisms[1][2][4][5].
02
Targets
BGT1 (Betaine/GABA transporter 1)DAT (Dopamine plasma membrane transport protein)SLC6A1 (Sodium- and chloride-dependent GABA transporter 1)GAT2 (Sodium- and chloride-dependent GABA transporter 2)GAT-3 (Sodium- and chloride-dependent GABA transporter 3)TACR2 (Neurokinin-2 Receptor)NET (Norepinephrine Transporter)SERT (Sodium-dependent serotonin transporter)
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