scaling and root planing + rosuvastatin

SRP + RSV refers to the combination of Scaling and Root Planing (SRP), a standard mechanical periodontal therapy, and the local delivery of a 1.2% rosuvastatin (RSV) in situ gel. This therapeutic approach is specifically investigated for the treatment of intrabony defects in patients with chronic periodontitis. Rosuvastatin is a synthetic, hydrophilic HMG-CoA reductase inhibitor (statin) that, when delivered subgingivally, exerts pleiotropic effects including potent anti-inflammatory activity and osteostimulative properties. It promotes bone regeneration by enhancing osteoblast differentiation and the expression of bone morphogenetic protein-2 (BMP-2), while inhibiting osteoclast-mediated bone resorption. The 1.2% rosuvastatin gel is typically formulated in a methylcellulose-based vehicle to provide controlled, local drug delivery directly into the periodontal pocket. This combination has been studied in randomized controlled trials, notably by the Government Dental College and Research Institute in Bengaluru, India, to compare its efficacy against other statins like atorvastatin.

Other names

SRP + RSV1.2% rosuvastatin gelrosuvastatin 1.2% in situ gelrosuvastatin 1.2% gel