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scfDNA + polyethylenimine
- Development stage
- Preclinical
- Lead developer
- Mayo Clinic
- Modality
- DNA Therapeutics → Nucleic Acid Therapeutics, Biodegradable Polymers → Polymer-based Nanoparticles → Nanoparticles → Drug Delivery Systems
- Administration
- Intravenous, Intraperitoneal, Intratumoral, Subcutaneous, Topical, Intrathecal, Intravitreal, Intranasal, Intra-arterial
01
Overview
scfDNA + polyethylenimine is an experimental DNA nanocarrier designed to mimic the proinflammatory effects of placental cell-free DNA (cfDNA) observed during pregnancy. It consists of a synthetic mimic of fetal cfDNA (scfDNA) complexed with the cationic polymer polyethylenimine (PEI) to facilitate cytosolic delivery. The drug targets the cyclic GMP-AMP synthase (cGAS)-stimulator of interferon genes (STING) pathway in monocytes and macrophages. By activating the cGAS-STING-IRF signaling axis, it induces a proinflammatory phenotype in tumor-associated macrophages (TAMs), potentially overcoming the immunosuppressive tumor microenvironment. This pregnancy-inspired approach is being developed as a strategy for cancer immunotherapy, specifically for reprogramming myeloid cells within the tumor.
- Other names
- scfDNA-PEI nanoparticlessynthetic fetal cfDNA-polyethylenimine complex
02
Targets
STING (Stimulator of interferon genes protein)Cyclic GMP–AMP synthase
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