Drug intelligence / Profile preview

seawater + sodium thiosulfate pentahydrate + sodium hyaluronate

Development stage
Unknown
Lead developer
Hope Pharmaceuticals
Modality
Implantable Hydrogels → Hydrogel Systems → Drug Delivery Systems, Small Molecules, Non-biodegradable Polymers → Polymer-based Nanoparticles → Nanoparticles → Drug Delivery Systems, Biodegradable Polymers → Polymer-based Nanoparticles → Nanoparticles → Drug Delivery Systems, Injectable Hydrogels → Hydrogel Systems → Drug Delivery Systems
Administration
Topical, Ophthalmic, Intranasal
01

Overview

This is a **combination product** containing seawater, sodium thiosulfate pentahydrate, and sodium hyaluronate. - **Seawater** is commonly used as an isotonic or hypertonic diluent in nasal or ophthalmic products to flush, hydrate, or cleanse mucosal surfaces but has no pharmacologically specific activity. - **Sodium thiosulfate pentahydrate** is an inorganic compound best known for its use as an antidote in cyanide poisoning, as well as treatment for calciphylaxis and to reduce cisplatin-induced ototoxicity, primarily through its sulfur-donating, detoxifying, anti-calcification, antioxidant, and anti-inflammatory effects. Its mechanism involves providing sulfur for detoxification and chelation[1][3][4]. - **Sodium hyaluronate** is the sodium salt of hyaluronic acid, widely used for lubrication, moisturizing, and as a wound-healing adjunct in ophthalmic, dermatologic, and joint products; it binds and retains water, forming a viscoelastic protective film. This specific combination may be formulated for topical, ophthalmic, or mucosal administration, aiming to combine osmoprotective, detoxifying, anti-inflammatory, and lubricating actions.

02

Targets

TST (Thiosulfate sulfurtransferase)

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