Drug intelligence / Profile preview

secnidazole + albendazole

Development stage
Unknown
Lead developer
Lupin
Modality
Small Molecules
Administration
Oral
01

Overview

secnidazole + albendazole is a combination drug regimen investigated by the University of Cambridge for the treatment and prevention of giardiasis and soil-transmitted helminthiasis in pediatric populations. Secnidazole is a nitroimidazole anti-infective that works by damaging the DNA of anaerobic protozoa like *Giardia lamblia*. Albendazole is a broad-spectrum benzimidazole anthelmintic that inhibits the polymerization of tubulin, disrupting the metabolic pathways of helminths. This specific co-administration strategy was evaluated in rural Bangladesh to assess its impact on infant growth, nutritional status, and intestinal mucosal function.

Other names
Anti-Giardia and antihelmintic treatment
02

Targets

TUBB (Tubulin (alpha and beta subunits))CYP2C19 (Cytochrome P450 2C19)DNACYP3A4 (Cytochrome P450 3A4)

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