second-generation cephalosporin + nitrofurantoin + aminoglycoside-Children's Hospital, Dziekanów Leśny, Poland-squamous metaplasia of the urinary bladder

This therapeutic protocol was developed and evaluated by the Children's Hospital in Dziekanów Leśny, Poland, for the treatment of non-keratinised stratified squamous metaplasia (N-KSM) of the urinary bladder in pediatric patients. The regimen consists of an initial 10-day course of a second-generation cephalosporin, followed by a three-month maintenance phase involving alternating chemotherapeutics, specifically nitrofurantoin, administered in therapeutic doses with weekly rotations. The protocol also incorporates a 1% aminoglycoside solution, which is typically administered intravesically. This multi-drug approach is designed to eradicate chronic bacterial colonization or recurrent infection, which are considered primary drivers of the pathological transformation of the bladder urothelium into squamous tissue.

Other names

second-generation cephalosporin + nitrofurantoin + aminoglycosidecephalosporin with chemotherapeutics