selective serotonin reuptake inhibitor + clomipramine

**selective serotonin reuptake inhibitor + clomipramine** is a combination therapy used primarily in the treatment of obsessive-compulsive disorder (OCD) among patients who do not respond adequately to SSRI monotherapy[1][2][3]. SSRIs increase serotonin levels by inhibiting its reuptake at the synapse, while clomipramine, a tricyclic antidepressant, also strongly inhibits serotonin reuptake and has additional mild antagonism at dopamine receptors[4]. When used together, the combination potentiates serotonergic neurotransmission beyond what can be achieved with either drug alone. Although there is evidence for enhanced efficacy, there is also significant risk of pharmacokinetic and pharmacodynamic drug interactions, including increased risk for QTc prolongation, seizures, and serotonergic overstimulation. Careful monitoring of plasma drug levels and cardiac function is recommended[1][2][3].

Other names

SSRI + clomipramine