Drug intelligence / Profile preview

selegiline + shudipingchan

Development stage
Unknown
Lead developer
Longhua Hospital Shanghai University of Traditional Chinese Medicine
Modality
Peptides, Small Molecules
Administration
Oral
01

Overview

Selegiline + shudipingchan is a combination therapy being investigated for the treatment of Parkinson's disease. It consists of the pharmaceutical drug selegiline, a selective irreversible monoamine oxidase type B (MAO-B) inhibitor, and Shudipingchan, a Traditional Chinese Medicine (TCM) herbal formula developed at Longhua Hospital. Selegiline works by inhibiting the breakdown of dopamine in the brain, thereby increasing dopaminergic activity. Shudipingchan is typically composed of herbs such as Rehmannia glutinosa (Shu Di Huang) and other components intended to nourish the 'kidney and liver yin' and extinguish 'wind' to alleviate tremors, according to TCM principles. The combination aims to provide synergistic effects, potentially enhancing motor function and reducing the side effects or dosage requirements of standard dopaminergic therapies like levodopa.

Other names
selegiline and shudipingchan granuleselegiline plus shudipingchan
02

Targets

MAOB (Monoamine oxidase B)P4HB (Protein disulfide-isomerase)MAOA (Monoamine oxidase A)

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