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Selenium + omega-3 fatty acids is a combination product typically comprising a selenium supplement (often as organic selenium yeast) and omega-3 fatty acids (commonly from fish oil, rich in EPA and DHA). This combination has been investigated for multiple indications, including nutritional support, cardiovascular health, rheumatoid arthritis, and adjunctive cancer therapy. Preclinical studies suggest this combination can synergistically induce endoplasmic reticulum (ER) stress-associated apoptosis, suppress epithelial-mesenchymal transition (EMT), and reverse tumor resistance mechanisms—particularly in non-small cell lung cancer (NSCLC) resistant to EGFR tyrosine kinase inhibitors by modulating ER stress response markers (such as CHOP, GRP78), β-catenin, and cyclooxygenase-2 (COX-2)[1][2][3]. In nutritional and cardiovascular contexts, selenium acts as a cofactor for antioxidant enzymes such as glutathione peroxidase, while omega-3 fatty acids decrease inflammatory mediators and improve lipid profiles; together, this may enhance antioxidant status, support immune function, and lower cardiovascular risk[5][6][7].
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