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selenium + triamcinolone acetonide

Development stage
Preclinical
Lead developer
Apothecon
Modality
Orthosteric Ligands → Classical Binding Small Molecules → Small Molecules
Administration
Topical
01

Overview

This is a combination drug consisting of selenium and triamcinolone acetonide. Selenium is an essential trace element with antioxidant properties, often used as a dietary supplement or adjunct in various conditions due to its role in reducing oxidative stress. Triamcinolone acetonide is a synthetic corticosteroid with potent anti-inflammatory and immunosuppressive effects, commonly used topically or by injection for inflammatory skin diseases and autoimmune conditions. The combination has been studied experimentally as a topical therapy for oral lichen planus (OLP), where the antioxidant effect of selenium may complement the anti-inflammatory action of triamcinolone acetonide to improve lesion healing and symptom control[1]. The mechanism involves reduction of local inflammation (triamcinolone) and mitigation of oxidative stress (selenium).

Other names
selenium and triamcinolone acetonideselenium plus triamcinolone acetonide
02

Targets

GR (Glucocorticoid receptor)

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