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semaglutide + empagliflozin + pioglitazone
- Development stage
- Phase 3
- Lead developer
- Sun Yat-sen University
- Modality
- Small Molecules, Peptides
- Administration
- Oral, Subcutaneous
01
Overview
"Group A" refers to an investigational triple combination therapy regimen consisting of semaglutide, empagliflozin, and pioglitazone. This regimen is being evaluated in a Phase 3 clinical trial (NCT06946628) led by Sun Yat-sen University for the treatment of newly diagnosed type 2 diabetes mellitus (T2DM). The strategy aims to achieve diabetes remission and preserve beta-cell function by combining three distinct mechanisms: GLP-1 receptor agonism (semaglutide), SGLT2 inhibition (empagliflozin), and PPAR-gamma activation (pioglitazone). This "early triple therapy" approach is compared against standard metformin-based stepwise treatment to determine its efficacy in improving glycemic control and achieving long-term remission.
- Other names
- early triple combination therapytriple combination therapy (semaglutide, empagliflozin, pioglitazone)
02
Targets
GLP1R (GLP-1R)PPARA (Peroxisome proliferator-activated receptor alpha)PPARG (Peroxisome proliferator-activated receptor gamma)SLC5A1 (Sodium Glucose Cotransporter 1)SGLT2 (Sodium-glucose cotransporter protein subunit 2)
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