Clinical trials
Full profile accessFollow clinical development from study design and recruitment through results.
- Trial phase
- Status
- Readouts
Drug intelligence / Profile preview
semi-allogenic human fibroblast (MRC-5)
- Development stage
- Preclinical
- Lead developer
- J.P. Jacobs
- Modality
- Cell Therapies, Vaccines & Immunotherapeutics
- Administration
- Intradermal
01
Overview
MRC-5 is a human diploid cell line composed of fibroblasts, originally developed in 1966 from the lung tissue of a 14-week-old aborted male fetus. This cell line is extensively used in biomedical research, particularly as a substrate for the production of various viral vaccines, including those for hepatitis A, varicella, polio, rubella, and rabies. In the context of a therapeutic agent, "semi-allogenic human fibroblast (MRC-5)" refers to an experimental vaccine approach where MRC-5 cells are transfected with autologous tumor DNA. This modification allows the MRC-5 cells to express tumor-associated antigens, which are then presented to the immune system. The goal is to activate a cytotoxic T-lymphocyte (CTL) response against cancer cells, thereby exhibiting potential immunostimulatory and antineoplastic activities.
- Other names
- Human fetal lung fibroblast (MRC-5)
Beyond the preview
Go deeper on semi-allogenic human fibroblast (MRC-5).
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Indications & development
Full profile accessExplore development by indication, patient population, and geography.
- Indications
- Development status
- Countries
Licensing & deals
Full profile accessTrace asset ownership, licensing agreements, and commercial partnerships.
- Partners
- Deal terms
- Milestones
Patents & exclusivity
Full profile accessExplore the patent landscape and regulatory exclusivity around an asset.
- Patents
- Expiration dates
- Exclusivity
Competitive landscape
Full profile accessCompare development programs by target, modality, and indication.
- Competing assets
- Targets
- Development stage
Research & analysis
Full profile accessConnect source evidence and development news to your research questions.
- Publications
- News
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on semi-allogenic human fibroblast (MRC-5).