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setrobuvir + peginterferon alfa-2a + ribavirin
- Development stage
- Phase 2
- Lead developer
- Roche
- Modality
- Small Interfering RNA (siRNA) → Small RNA Therapeutics → RNA Therapeutics → Nucleic Acid Therapeutics, MicroRNA (miRNA) → Small RNA Therapeutics → RNA Therapeutics → Nucleic Acid Therapeutics, Antisense Oligonucleotides (ASOs) → Long RNA Therapeutics → RNA Therapeutics → Nucleic Acid Therapeutics, Antisense DNA → DNA Therapeutics → Nucleic Acid Therapeutics, Small Molecules, Recombinant Proteins and Enzymes
- Administration
- Oral, Subcutaneous
01
Overview
**Setrobuvir + peginterferon alfa-2a + ribavirin** is a triple combination therapy evaluated for the treatment of chronic hepatitis C virus (HCV) infection, specifically genotype 1, in treatment-naïve patients. - **Setrobuvir** is a small molecule inhibitor targeting the HCV NS5B non-nucleoside polymerase, blocking viral RNA replication. - **Peginterferon alfa-2a** is a recombinant pegylated form of interferon alpha, working as an immunomodulator that enhances the host's antiviral defense by binding to the interferon alpha receptor and promoting expression of genes involved in viral clearance. - **Ribavirin** is a nucleoside analogue with broad-spectrum antiviral activity, interfering with viral RNA synthesis and inducing lethal mutagenesis in the HCV genome. When used together, the combination aims to induce a sustained virologic response (SVR), measured by undetectable levels of HCV RNA 24 weeks after completing therapy. Clinical studies have tested this regimen with a lead-in phase of peginterferon alfa-2a and ribavirin, followed by the addition of setrobuvir, typically administered orally alongside subcutaneous peginterferon alfa-2a and oral ribavirin[3].
- Other names
- setrobuvir + peginterferon alfa-2a + ribavirin
02
Targets
NS5B (Hepatitis C virus non-structural protein 5B (NS5B) RNA-dependent RNA polymerase)IFNAR (Immune system modulation via type I interferon receptor)HCV RNA (Hepatitis C virus RNA)
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