sevelamer carbonate + calcitriol

Sevelamer carbonate + calcitriol is a combination therapy used primarily in patients with chronic kidney disease (CKD), especially those on dialysis. Sevelamer carbonate is a non-calcium, non-aluminum phosphate binder that acts by binding dietary phosphate in the gastrointestinal tract, thereby reducing serum phosphorus levels. Calcitriol is the active form of vitamin D3 and works as a vitamin D receptor agonist to regulate calcium and phosphate homeostasis by increasing intestinal absorption of calcium and suppressing parathyroid hormone (PTH) secretion. This combination addresses both hyperphosphatemia and secondary hyperparathyroidism commonly seen in CKD patients. However, co-administration can reduce the bioavailability of oral calcitriol due to binding interactions in the gut[3][5]. The combined use has been shown to improve therapeutic outcomes for controlling serum phosphorus and PTH levels in CKD[6][8].

Other names

1,25-dihydroxyvitamin D3 (for calcitriol)poly(allylamine hydrochloride) (for sevelamer carbonate)