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sevoflurane + isoflurane
- Development stage
- Unknown
- Lead developer
- University Medical Center Utrecht
- Modality
- Small Molecules
- Administration
- Inhalation
01
Overview
This entry describes a clinical trial comparison conducted by the University Medical Center (UMC) Utrecht evaluating the hemodynamic effects of sevoflurane versus isoflurane. Both are halogenated volatile anesthetic agents used for the induction and maintenance of general anesthesia. The study, designed as a randomized crossover trial, specifically investigated the incidence of hypotension and the requirement for vasopressor support (such as phenylephrine) in patients undergoing elective coronary artery bypass grafting (CABG). Sevoflurane and isoflurane act primarily as positive allosteric modulators of GABA-A receptors and antagonists of NMDA receptors within the central nervous system, though they differ slightly in their solubility and impact on systemic vascular resistance.
- Brand names
- UltaneSevoraneForaneAerane
- Other names
- volatile anestheticshalogenated ethers
02
Targets
KCNK2 (Potassium channel subfamily K member 2)GABRR (GABA-A receptor subunit rho)Nicotinic Acetylcholine ReceptorGlycine receptorNMDAR (Glutamate receptor ionotropic, NMDA)
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